Endocrine Abstracts

Objective: Previous studies indicated that two glucocorticoid receptor gene polimorphisms bclI and N363S (GC-S) are associated with increased sensitivity to glucocorticoids and two other polymorphisms 9β and ER22/23EK (GC-I) are related to decreased sensitivity to glucocorticoids. The aim of the study was to determine whether these genetic changes can effect on the occurence of steroid-induced adverse events.Methods: One hundred and fifty p...

Introduction: Parabens are a group of chemicals used as preservatives in the food, cosmetic and pharmaceutical industries. They are known to possess estrogenic effects, and therefore have been classified as endocrine disruptors. In addition to the classical endocrine organs, other tissues have endocrine activity, including adipose tissue. Several chemicals are known to cause obesogenic effects, and parabens are currently being studied in this context. The aim of this study was...

Introduction: In ATA recommendations (2016) a delayed risk stratification (DRS) system proposed by D.P. Momesso et al. was accepted as a diagnostic tool for the risk stratification of unfavorable clinical outcome and for monitoring the clinical outcome in differentiated thyroid cancer (DTC) patients treated without radioactive iodine (RAI).The aim of the study: To evaluate the DRS system in patients with low clinical stage (pT1aN0/Nx).<p class="abste...

Context: Hypothalamic obesity, subsequent cardiovascular disease (CVD), and relapses/progression have major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging (MRI) performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP.Objective: Identify association of NST with body mass index (BMI), waist-to-height ratio (WHtR), caliper-assess...

Thyroid function in pregnancy differs between populations. The aim of the study was to assess thyroid parameters in Polish pregnant women. It included 1095 pregnant volunteers aged 16–42 years (174, 501, 420 in the 1st, 2nd, and 3rd trimester, respectively), who gave their informed written consent. In each woman thyroid ultrasound was performed, 90.7% had TSH, fT4 and a-TPO measured, and 84.0% iodine urinary concentration (UIC) in urine spot sample estimated.<p class=...

Introduction: The prevalence of polycystic ovary syndrome (PCOS) is increased in women with type 1 diabetes (T1DM) in comparison to the general population. It has been suggested that exogenous insulin administered to T1DM women in supraphysiological doses could act as co-gonadotropin and lead to disturbances observed in PCOS.Aim: The aim of this study was to evaluate the phenotypic characteristic and differences between diabetic women with PCOS (T1DM+PCO...

Introduction: Brain derived neurotrophic factor (BDNF) is a neurotrophin which plays a role in neuronal growth and differentiation. Decreased level of BDNF is supposed to play a role in the pathogenesis of the neurodegenerative diseases. Recent data indicate that BDNF could be also involved in angiogenesis. Several lines of evidence support the role of BDNF in glucose metabolism. The decreased level of BDNF are observed in obesity and type 2 diabetes mellitus. Polycystic ovary...

ACTH test is widely accepted as diagnostic tool in suspicion on peripheral as well as on central hypocorticism. The optimal dose of tetracosactide for determination of hypocorticism is still matter of debate. The 250 μg as a standard dose of tetracosactide has been approved for diagnosis of congenital adrenal hyperplasia (CAH) many years ago. Moreover, current limited availability of tetracosactide and its increased financial cost on the market raised the question whether...

Introduction: Molecular testing play increasingly a significant role in pre-operative diagnosis of nodular goiter, as standard methods may not give conclusive decision in choosing optimal treatment approach. BRAF gene mutations are often discovered in the cytological specimens among the patients with papillary thyroid cancer. The aim of the study was to assess the incidence of BRAF T1799A mutation in cellular specimens derived from fine needle aspiration biopsy (FNAB)...

Introduction: Congenital hypothyroidism (CH) is the most common congenital endocrine disorder. It occurs in Europe with an incidence of 1:3000–1:4000.Thyroid dysgenesis – agenesis, hypoplasia or ectopy – is responsible for 80–90% of CH cases. An ectopic thyroid gland is an uncommon inborn anomaly and is typically located along the thyroglossal duct. To date only few cases of CH due to lingual thyroid diagnosed in adulthood were reported in the literature.</...